Single-cell omics technologies provide an unprecedented opportunity to deciphermolecular mechanisms underlying various biological processes in a cellularheterogeneity manner. The emergence of such techniques promotes the explorationof lncRNAs, which are known to be tissue- and cell-specific noncodingtranscripts involving the regulation of multiple important cellular processes.In this review, we introduce the advancement of lncRNA studies which benefitfrom single-cell omics data analysis. We discuss the expression heterogeneity oflncRNAs, their cell-type specificity and associated gene regulatory networks(GRNs) from a single-cell perspective. We also summarized the state-of-the-artsingle-cell omics resources and tools for the construction of single-cell GRNs(scGRNs) that could be potentially used for lncRNA functional study. Finally, wehighlight the challenges and prospective for scGRN exploration in lncRNAbiology.